A cell-free approach with a supporting biomaterial in the form of dispersed microspheres induces hyaline cartilage formation in a rabbit knee model
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| dc.contributor.author | Zurriaga Carda, Javier
|
es_ES |
| dc.contributor.author | Lastra, Maria L.
|
es_ES |
| dc.contributor.author | Antolinos-Turpin, Carmen M.
|
es_ES |
| dc.contributor.author | Morales-Román, Rosa M.
|
es_ES |
| dc.contributor.author | Sancho-Tello, María
|
es_ES |
| dc.contributor.author | Perea-Ruiz, Sofía
|
es_ES |
| dc.contributor.author | Milián, Lara
|
es_ES |
| dc.contributor.author | Fernández, Juan M.
|
es_ES |
| dc.contributor.author | Cortizo, Ana M.
|
es_ES |
| dc.contributor.author | Carda, Carmen
|
es_ES |
| dc.contributor.author | Gallego-Ferrer, Gloria
|
es_ES |
| dc.contributor.author | Gómez Ribelles, José Luís
|
es_ES |
| dc.date.accessioned | 2021-07-21T03:31:13Z | |
| dc.date.available | 2021-07-21T03:31:13Z | |
| dc.date.issued | 2020-05 | es_ES |
| dc.identifier.issn | 1552-4973 | es_ES |
| dc.identifier.uri | http://hdl.handle.net/10251/169640 | |
| dc.description.abstract | [EN] The objective of this study was to test a regenerative medicine strategy for the regeneration of articular cartilage. This approach combines microfracture of the subchondral bone with the implant at the site of the cartilage defect of a supporting biomaterial in the form of microspheres aimed at creating an adequate biomechanical environment for the differentiation of the mesenchymal stem cells that migrate from the bone marrow. The possible inflammatory response to these biomaterials was previously studied by means of the culture of RAW264.7 macrophages. The microspheres were implanted in a 3¿mm-diameter defect in the trochlea of the femoral condyle of New Zealand rabbits, covering them with a poly(l-lactic acid) (PLLA) membrane manufactured by electrospinning. Experimental groups included a group where exclusively PLLA microspheres were implanted, another group where a mixture of 50/50 microspheres of PLLA (hydrophobic and rigid) and others of chitosan (a hydrogel) were used, and a third group used as a control where no material was used and only the membrane was covering the defect. The histological characteristics of the regenerated tissue have been evaluated 3 months after the operation. We found that during the regeneration process the microspheres, and the membrane covering them, are displaced by the neoformed tissue in the regeneration space toward the subchondral bone region, leaving room for the formation of a tissue with the characteristics of hyaline cartilage. | es_ES |
| dc.description.sponsorship | Comisión de Investigaciones Científicas de la Provincia de Buenos Aires (CICPBA), Universidad Nacional de La Plata, Grant/Award Number: 11/X643; Agencia Estatal de Investigación/Fondo Europeo de Desarrollo Regional de la Unión Europea, Grant/Award Number: MAT2016-76039-C4-1 2-R; Spanish Ministry of Economy and Competitiveness (MINECO) | es_ES |
| dc.language | Inglés | es_ES |
| dc.publisher | John Wiley & Sons | es_ES |
| dc.relation.ispartof | Journal of Biomedical Materials Research Part B Applied Biomaterials | es_ES |
| dc.rights | Reserva de todos los derechos | es_ES |
| dc.subject | Articular cartilage regeneration | es_ES |
| dc.subject | Cartilage engineering | es_ES |
| dc.subject | Chitosan | es_ES |
| dc.subject | Microspheres | es_ES |
| dc.subject | Polylactide | es_ES |
| dc.subject | Rabbit knee model | es_ES |
| dc.subject.classification | MAQUINAS Y MOTORES TERMICOS | es_ES |
| dc.title | A cell-free approach with a supporting biomaterial in the form of dispersed microspheres induces hyaline cartilage formation in a rabbit knee model | es_ES |
| dc.type | Artículo | es_ES |
| dc.identifier.doi | 10.1002/jbm.b.34490 | es_ES |
| dc.relation.projectID | info:eu-repo/grantAgreement/UNLP//11%2FX643/ | es_ES |
| dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//MAT2016-76039-C4-1-R/ES/BIOMATERIALES PIEZOELECTRICOS PARA LA DIFERENCIACION CELULAR EN INTERFASES CELULA-MATERIAL ELECTRICAMENTE ACTIVAS/ | es_ES |
| dc.rights.accessRights | Abierto | es_ES |
| dc.contributor.affiliation | Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada | es_ES |
| dc.description.bibliographicCitation | Zurriaga Carda, J.; Lastra, ML.; Antolinos-Turpin, CM.; Morales-Román, RM.; Sancho-Tello, M.; Perea-Ruiz, S.; Milián, L.... (2020). A cell-free approach with a supporting biomaterial in the form of dispersed microspheres induces hyaline cartilage formation in a rabbit knee model. Journal of Biomedical Materials Research Part B Applied Biomaterials. 108(4):1428-1438. https://doi.org/10.1002/jbm.b.34490 | es_ES |
| dc.description.accrualMethod | S | es_ES |
| dc.relation.publisherversion | https://doi.org/10.1002/jbm.b.34490 | es_ES |
| dc.description.upvformatpinicio | 1428 | es_ES |
| dc.description.upvformatpfin | 1438 | es_ES |
| dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
| dc.description.volume | 108 | es_ES |
| dc.description.issue | 4 | es_ES |
| dc.identifier.pmid | 31520507 | es_ES |
| dc.relation.pasarela | S\405032 | es_ES |
| dc.contributor.funder | European Regional Development Fund | es_ES |
| dc.contributor.funder | Universidad Nacional de La Plata, Argentina | es_ES |
| dc.contributor.funder | Ministerio de Economía y Competitividad | es_ES |
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| dc.subject.ods | 03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades | es_ES |
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