Título: Protein-Functionalized Microgel for Multiple Myeloma Cells’ 3D Culture
Autor: Marín Pallá, Juan Carlos; Clara Trujillo, Sandra; Cordón, Lourdes; Gallego Ferrer, Gloria; Sempere, Amparo; Gómez Ribelles, José Luís
Resumen: Multiple myeloma is a hematologic neoplasm caused by an uncontrolled clonal proliferation
of neoplastic plasma cells (nPCs) in the bone marrow. The development and survival of this disease is
tightly related to the bone marrow environment. Proliferation and viability of nPCs depend on their
interaction with the stromal cells and the extracellular matrix components, which also influences the
appearance of drug resistance. Recapitulating these interactions in an in vitro culture requires 3D
environments that incorporate the biomolecules of interest. In this work, we studied the proliferation
and viability of three multiple myeloma cell lines in a microgel consisting of biostable microspheres
with fibronectin (FN) on their surfaces. We also showed that the interaction of the RPMI8226 cell line
with FN induced cell arrest in the G0/G1 cell cycle phase. RPMI8226 cells developed a significant
resistance to dexamethasone, which was reduced when they were treated with dexamethasone and
bortezomib in combination.