Resumen: [EN] The paper aims to describe the contribution of Vinnytsia Mykhailo Kotsiubynskyi State Pedagogical University [VSPU] to e-learning in Ukraine that served as a momentum for cardinal transformations in the formats of instruction, content, and engagement of Ukrainian students and professors. With institutional priorities, faculty members’ Fulbright commitments and initiatives, and collaborative support of Southeast Missouri State University [SEMO], USA, VSPU has significantly improved technology literacy, intercultural competence, and attitudes to innovation in teacher candidates. The research is empirically based on over ten years of online experimenting with project work that organically became part of university teacher training curricula. The research applies SWOT analysis and qualitative and quantitative methods. The findings demonstrate the evident attitudinal change toward e-education and international collaboration with years of engagement, resulting in relevant teacher preparation. The research concludes that changes in educational trajectories are beneficial and necessary to address global and local challenges.