The role of the interfaces and cross-links on the mechanical behavior of mineralized collagen fibrils. A numerical approach
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| dc.contributor.author | Vercher Martínez, Ana
|
es_ES |
| dc.contributor.author | Giner Maravilla, Eugenio
|
es_ES |
| dc.contributor.author | Fuenmayor, F. Javier
|
es_ES |
| dc.contributor.author | García-Aznar, J. Manuel
|
es_ES |
| dc.date.accessioned | 2025-02-27T19:03:10Z | |
| dc.date.available | 2025-02-27T19:03:10Z | |
| dc.date.issued | 2024-10-01 | es_ES |
| dc.identifier.issn | 0013-7944 | es_ES |
| dc.identifier.uri | http://hdl.handle.net/10251/214927 | |
| dc.description.abstract | [EN] Mechanical properties of bone tissue are highly dependent on its hierarchical structure. The presence of microcracks and diffuse damage in lamellar bone is correlated with the failure of the collagen-mineral interface in mineralized collagen fibrils (MCF). The main goal of this work is to evaluate the mechanical behavior of the interfaces and quantify the stiffness loss of the MCF associated with different failure mechanisms, under controlled in-plane displacement. Additionally, we aim to study the role of the cross-links on the fibril mechanical response, beyond the interface failure. Inter- and intra-microfibrilar cross-links are analyzed. In order to address the first issue, a detailed representative volume of the MCF is analyzed by means of the finite element method, under the assumption of plane strain and periodic boundary conditions. In this model the interfaces between constituents are modeled with an exponential cohesive law. Enzymatic cross-links, located at the molecular terminals connecting each 4D (D = 67 nm) staggered molecules, are represented by non-linear springs. Three in-plane controlled deformations are applied. The results of this work provide the anisotropic stiffness loss of the tissue involved in the different failure mechanisms at the nano-scale length. The initiation of microcracks and the presence of damage zones are compatible with the failure mechanisms observed at interfaces. Interface failure entails a progressive stiffness loss, bringing a non-linear behavior of bone. The strength obtained for the longitudinal maximum deformation is more than 20 times the transverse strength and 3.5 times the shear strength. The quantification of the reduction percentage in the elastic moduli and the shear stiffness when the fibril is damaged, has a potential application in improving failure criteria based on degradation of elastic constants. When longitudinal elongation is applied, the mechanical contribution of the cross-links in delaying the failure initiation of the interface is shown. Likewise, results of this work confirm the scarce influence of the cross-links in the strain range analyzed. Additionally, a threedimensional numerical model of several microfibrils is defined with the aim of analyzing the mechanical relevance of inter- and intra-microfibrilar cross-links, beyond the interface failure. Results confirm that cross-links transfer the load when strain increases, being highlighted the mechanical competence of the trivalent cross-links. | es_ES |
| dc.description.sponsorship | The authors acknowledge the Ministerio de Ciencia e Innovacion y Universidades and the European Regional Development Fund (FEDER) for the financial support received through the projects PID2020-118920RB-I00, PID2020-118480RB-C21 and C22 funded by MCIN/AEI/10.13039/501100011033 and by "ERDF A way of making Europe", the Ministerio de Ciencia e Innovacion y Universidades MCIN/AEI/10.13039/501100011033 and Europe Union Next Generation EU/PRTR for the projects PDC2021-121368-C21 and C22, CRUE-Universitat Politecnica de Valencia and the Generalitat Valenciana for Programa PROMETEO/2021/046. | es_ES |
| dc.language | Inglés | es_ES |
| dc.publisher | Elsevier | es_ES |
| dc.relation.ispartof | Engineering Fracture Mechanics | es_ES |
| dc.rights | Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) | es_ES |
| dc.subject | Mineralized collagen fibril | es_ES |
| dc.subject | Interfaces | es_ES |
| dc.subject | Failure mechanisms | es_ES |
| dc.subject | Cohesive law | es_ES |
| dc.subject | Stiffness loss | es_ES |
| dc.subject | Cross-link | es_ES |
| dc.subject | Finite element method | es_ES |
| dc.subject.classification | INGENIERIA MECANICA | es_ES |
| dc.title | The role of the interfaces and cross-links on the mechanical behavior of mineralized collagen fibrils. A numerical approach | es_ES |
| dc.type | Artículo | es_ES |
| dc.identifier.doi | 10.1016/j.engfracmech.2024.110440 | es_ES |
| dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PDC2021-121368-C22/ES/VIRTUAL TESTING OF DRILLED HYBRID CFRP%2FMETAL COMPONENTS FOR SERVICE LIFE ASSURANCE/ | es_ES |
| dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-118480RB-C21/ES/ENSAYO MECANICO DE LAMINADOS CON DEFECTOS Y SIMULACION NUMERICA/ | es_ES |
| dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-118480RB-C22/ES/ANALISIS DE DEFECTOS EN LAMINADOS REFORZADOS CON FIBRAS DEBIDOS A PROCESOS DE FABRICACION Y EFECTO EN EL COMPORTAMIENTO A FATIGA/ | es_ES |
| dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-118920RB-I00/ES/EVALUACION DEL RIESGO DE FRACTURA OSEA CON PREVALENCIA DE OSTEOPOROSIS MEDIANTE UN ENFOQUE MULTIESCALA/ | es_ES |
| dc.relation.projectID | info:eu-repo/grantAgreement/GVA//PROMETEO%2F2021%2F046/ES/MODELADO NUMÉRICO AVANZADO EN INGENIERÍA MECÁNICA/ | es_ES |
| dc.rights.accessRights | Abierto | es_ES |
| dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingenieros Industriales - Escola Tècnica Superior d'Enginyers Industrials | es_ES |
| dc.description.bibliographicCitation | Vercher Martínez, A.; Giner Maravilla, E.; Fuenmayor, FJ.; García-Aznar, JM. (2024). The role of the interfaces and cross-links on the mechanical behavior of mineralized collagen fibrils. A numerical approach. Engineering Fracture Mechanics. 309. https://doi.org/10.1016/j.engfracmech.2024.110440 | es_ES |
| dc.description.accrualMethod | S | es_ES |
| dc.relation.publisherversion | https://doi.org/10.1016/j.engfracmech.2024.110440 | es_ES |
| dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
| dc.description.volume | 309 | es_ES |
| dc.relation.pasarela | S\525081 | es_ES |
| dc.contributor.funder | GENERALITAT VALENCIANA | es_ES |
| dc.contributor.funder | AGENCIA ESTATAL DE INVESTIGACION | es_ES |
| dc.contributor.funder | Agencia Estatal de Investigación | es_ES |
| dc.contributor.funder | Universitat Politècnica de València | es_ES |
| upv.costeAPC | 3650 | es_ES |
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