On the Oral Microbiome of Oral Potentially Malignant and Malignant Disorders: Dysbiosis, Loss of Diversity, and Pathogens Enrichment
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| dc.contributor.author | Herreros-Pomares, Alejandro
|
es_ES |
| dc.contributor.author | Hervás-Marín, David
|
es_ES |
| dc.contributor.author | Bagán-Debón, Leticia
|
es_ES |
| dc.contributor.author | Jantus-Lewintre, Eloisa
|
es_ES |
| dc.contributor.author | Gimeno-Cardona, Concepción
|
es_ES |
| dc.contributor.author | Bagan, José
|
es_ES |
| dc.date.accessioned | 2025-02-27T19:03:12Z | |
| dc.date.available | 2025-02-27T19:03:12Z | |
| dc.date.issued | 2023-02 | es_ES |
| dc.identifier.uri | http://hdl.handle.net/10251/214929 | |
| dc.description.abstract | [EN] The role of dysbiosis in the development and progression of oral potentially malignant disorders (OPMDs) remains largely unknown. Here, we aim to characterize and compare the oral microbiome of homogeneous leucoplakia (HL), proliferative verrucous leukoplakia (PVL), oral squamous cell carcinoma (OSCC), and OSCC preceded by PVL (PVL-OSCC). Fifty oral biopsies from HL (n = 9), PVL (n = 12), OSCC (n = 10), PVL-OSCC (n = 8), and healthy (n = 11) donors were obtained. The sequence of the V3-V4 region of the 16S rRNA gene was used to analyze the composition and diversity of bacterial populations. In the cancer patients, the number of observed amplicon sequence variants (ASVs) was lower and Fusobacteriota constituted more than 30% of the microbiome. PVL and PVL-OSCC patients had a higher abundance of Campilobacterota and lower Proteobacteria than any other group analyzed. A penalized regression was performed to determine which species were able to distinguish groups. HL is enriched in Streptococcus parasanguinis, Streptococcus salivarius, Fusobacterium periodonticum, Prevotella histicola, Porphyromonas pasteri, and Megasphaera micronuciformis; PVL is enriched in Prevotella salivae, Campylobacter concisus, Dialister pneumosintes, and Schaalia odontolytica; OSCC is enriched in Capnocytophaga leadbetteri, Capnocytophaga sputigena, Capnocytophaga gingivalis, Campylobacter showae, Metamycoplasma salivarium, and Prevotella nanceiensis; and PVL-OSCC is enriched in Lachnospiraceae bacterium, Selenomonas sputigena, and Prevotella shahii. There is differential dysbiosis in patients suffering from OPMDs and cancer. To the best of our knowledge, this is the first study comparing the oral microbiome alterations in these groups; thus, additional studies are needed. | es_ES |
| dc.description.sponsorship | This work was supported by PI19/00790 from Fondo de Investigacion Sanitaria, ISCIII (PI: Jose Bagan). | es_ES |
| dc.language | Inglés | es_ES |
| dc.publisher | MDPI AG | es_ES |
| dc.relation.ispartof | International Journal of Molecular Sciences | es_ES |
| dc.rights | Reconocimiento (by) | es_ES |
| dc.subject | Oral leukoplakia | es_ES |
| dc.subject | Oral cancer | es_ES |
| dc.subject | Microbiota | es_ES |
| dc.subject | Head and neck cancer | es_ES |
| dc.subject | Pathogens | es_ES |
| dc.subject | Campylobacter | es_ES |
| dc.subject | 16S rRNA | es_ES |
| dc.subject.classification | BIOLOGIA CELULAR | es_ES |
| dc.subject.classification | ESTADISTICA E INVESTIGACION OPERATIVA | es_ES |
| dc.title | On the Oral Microbiome of Oral Potentially Malignant and Malignant Disorders: Dysbiosis, Loss of Diversity, and Pathogens Enrichment | es_ES |
| dc.type | Artículo | es_ES |
| dc.identifier.doi | 10.3390/ijms24043466 | es_ES |
| dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII//PI19%2F00790/ | es_ES |
| dc.rights.accessRights | Abierto | es_ES |
| dc.contributor.affiliation | Universitat Politècnica de València. Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural - Escola Tècnica Superior d'Enginyeria Agronòmica i del Medi Natural | es_ES |
| dc.description.bibliographicCitation | Herreros-Pomares, A.; Hervás-Marín, D.; Bagán-Debón, L.; Jantus-Lewintre, E.; Gimeno-Cardona, C.; Bagan, J. (2023). On the Oral Microbiome of Oral Potentially Malignant and Malignant Disorders: Dysbiosis, Loss of Diversity, and Pathogens Enrichment. International Journal of Molecular Sciences. 24(4). https://doi.org/10.3390/ijms24043466 | es_ES |
| dc.description.accrualMethod | S | es_ES |
| dc.relation.publisherversion | https://doi.org/10.3390/ijms24043466 | es_ES |
| dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
| dc.description.volume | 24 | es_ES |
| dc.description.issue | 4 | es_ES |
| dc.identifier.eissn | 1422-0067 | es_ES |
| dc.identifier.pmid | 36834903 | es_ES |
| dc.identifier.pmcid | PMC9961214 | es_ES |
| dc.relation.pasarela | S\485933 | es_ES |
| dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
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