Título: Human atria and torso 3D computational models for simulation of atrial arrhythmias

Autor: Sebastián Aguilar, Rafael; Ferrer Albero, Ana; Saiz Rodríguez, Francisco Javier

Resumen: Computational 3D models of human atria and torso with encoded anatomical and functional heterogeneity. The finite element model of the atria is a multi-layer mesh with a homogeneous wall thickness between 600 and 900 μm (754.893 nodes and 515.010 elements), built with linear hexahedral elements and with regular spatial resolution of 300 µm. The model consists of: 21 regions with 53 sub-divisions representing the detailed description of fibre orientation; electrophysiological heterogeneity represented by 8 cellular models with differences in the action potential properties; and conduction velocities and anisotropy ratios tuned to each atrial region. The torso was modelled using a dataset obtained from the online open repository at the Centre for Integrative Biomedical Computing (CBIC) from University of Utah. The torso model has 190.804 nodes and 1.149.531 tetrahedral elements with a spatial resolution of 0.6 mm. It has 6 different regions: lungs, bones, liver, ventricle, blood pools, and flesh.

Descripción: The atrial and torso dataset are unstructured grids built using the standard format vtk and can be visualized using the open access software Paraview (www.paraview.org). The file structure is the following: File: 2015_3D_AtrialModel.vtk DATASET UNSTRUCTURED_GRID POINTS Number_points float Number_points=754.893 nodes X1 Y1 Z1 X2 Y2 Z2 X3 Y3 Z3 (point coordinates) CELLS Number_cells (Number_cells)x2 Number_cells=515.010 elements 8 ei1 ei2 ei3 ei4 ei5 ei6 ei7 ei8 (hexahedral element ei connectivity) CELL_TYPES Number_cells 12 (hexahedral element) Type of element=hexahedral CELL_DATA Number_cells NORMALS fibers double Xf1 Yf1 Zf1 Xf2 Yf2 Zf2 Xf3 Yf3 Zf3 (fibre direction) 21 different fibre directions associated to each element depending on the anatomical región FIELD FieldData 2 OrganID 1 Number_cells double Organ ID associated to each of the 53 sub-regions with specific fibre direction o1 o2 o3 o4 o5 o6 o7 o8 (up to 53 sub-regions) POINT_DATA Number_points FIELD FieldData 3 material 1 Number_points double ma1 ma2 ma3 ma4 ma5 ma6 ma7 ma8 ma9 (up to 10 types of material) Material ID representing the longitudinal conductivity and anisotropy ratio for each type of atrial tissue model 1 Number_points double mo1 mo2 mo3 mo4 mo5 mo6 mo7 mo8 mo9 (up to 8 different cellular models) Model ID representing the electrophysiological heterogeneity of the atria (models are named from 191 to 198) File: 2015_3D_TorsoModel.vtk DATASET UNSTRUCTURED_GRID POINTS Number_points double Number_points=190.804 nodes X1 Y1 Z1 X2 Y2 Z2 X3 Y3 Z3 (point coordinates) CELLS Number_cells (Number_cells)x2 Number_cells=1.149.531elements 4 ei1 ei2 ei3 ei4 (tetrahedral element ei connectivity) CELL_TYPES Number_cells 10 (tetrahedral element) Type of element= tetrahedral FIELD FieldData 1 OrganID 1 Number_cells short o1 o2 o3 o4 o5 o6 o7 o8 (up to 6 different organs) Organ ID associated to each of the 6 regions with specific electrical conductivity (lungs, bones, liver, ventricle, blood pools, and flesh)

URI: http://hdl.handle.net/10251/55150

Fecha: 2015-09-28

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